Dr. Stephen Quake's interests lie at the nexus of physics, biology, and biotechnology. His research is concerned with developing new approaches to biological measurement and applying these approaches to problems of both fundamental and medical interest. Areas of interest include genomic diagnostics, systems biology, microbial ecology, and single cell genomics.
This work published in BMC Genomics features data supporting that "hypothermic storage of intact primary tissues in organ transplant preservative maintains the quality and stability of the transcriptome of cells for single cell RNAseq analysis."
A recent study published in Science from the Quake lab and professor of medicine, Mads Melbye, was mentioned in Stanford Medicine News. The study involves using pregnant women's blood to measure RNA fragments estimating the baby's due date which can predict if the baby will be born prematurely.The article in Stanford Medicine News states that "The tests could help reduce problems related to premature birth, which affects 15 million infants worldwide each year. Until now, doctors have lacked a reliable way to predict whether pregnancies will end prematurely, and have struggled to accurately predict delivery dates for all types of pregnancies, especially in low-resource settings." This is significant because researchers now have the resources to know in advance if a baby will be born prematurely allowing time for a Dr. to take necessary precautions to aid the baby and mother during birth.