The Quake Lab
Dr. Stephen Quake's interests lie at the nexus of physics, biology, and biotechnology. His research is concerned with developing new approaches to biological measurement and applying these approaches to problems of both fundamental and medical interest. Areas of interest include genomic diagnostics, systems biology, microbial ecology, and single cell genomics.
Cell types of origin of the cell-free transcriptome
This work published in Nature Biotech demonstrates how single cell transcriptomic atlases can be used to resolve cell-free RNA liquid biopsies at cell type resolution.
Brain Endothelial Cells Are Exquisite Sensors of Age Related Circulatory Cues
This work published in Cell Reports features data supporting that "the transcriptional age of brain endothelial cells is exquisitely sensitive to age-related circulatory cues and pinpoint the blood brain barrier itself as a promising therapeutic target to treat brain disease."