The Quake Lab
Dr. Stephen Quake's interests lie at the nexus of physics, biology, and biotechnology. His research is concerned with developing new approaches to biological measurement and applying these approaches to problems of both fundamental and medical interest. Areas of interest include single cell genomics, genomic diagnostics, microbial ecology, and systems biology.
Cell types of origin of the cell-free transcriptome
This work published in Nature Biotech demonstrates how single cell transcriptomic atlases can be used to resolve cell-free RNA liquid biopsies at cell type resolution.
Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle
This work published in Nature Medicine opens new vistas for women’s health through single-cell RNA sequencing of the uterus across the menstrual cycle, revealing human endometrial cell–specific preparation for embryo implantation, menstruation, and tissue renewal.
Brain Endothelial Cells Are Exquisite Sensors of Age Related Circulatory Cues
This work published in Cell Reports features data supporting that "the transcriptional age of brain endothelial cells is exquisitely sensitive to age-related circulatory cues and pinpoint the blood brain barrier itself as a promising therapeutic target to treat brain disease."
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
The Tabula Sapiens is a molecular reference atlas for more than 400 cell types of the human body.
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